At a glance
Sequence
KPV (α-MSH 11-13)
Molecular Weight
C16H30N4O4
CAS Number
67727-97-3
Purity
≥99%
Receptor
Anti-inflammatory (NF-κB)
Molecular Weight
342.4 Da
Reported Half-Life
~30 min
Storage
-20°C lyophilized
Reconstitution
BAC water
Overview
Tissue-repair peptides are investigated for their roles in angiogenesis, fibroblast activity, extracellular matrix remodeling, and inflammation resolution. Many derive from naturally-occurring fragments of larger repair proteins.
KPV is studied for its activity at Anti-inflammatory (NF-κB), with a reported half-life of ~30 min. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
VEGF / NO signaling, actin polymerization, and downregulation of pro-inflammatory transcription factors.
In published in-vitro work, KPV engages Anti-inflammatory (NF-κB) to initiate downstream signaling. The reported half-life of ~30 min informs typical dosing intervals in experimental protocols.
Research Applications
- Wound healing and cell migration assays
- Tendon and ligament repair models
- Angiogenesis (HUVEC, CAM) experiments
- NF-κB and cytokine modulation studies
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of KPV we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 342.4 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Senolytic research
Antioxidant pathway research
NAD metabolism research
Mitochondrial protection research
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≥99% purity · third-party tested · ships from the USA