At a glance
Receptor
MC3R / MC4R
Molecular Weight
1025.2 Da
Reported Half-Life
~2 hr
Storage
-20°C lyophilized, dark
Molecular Formula
C50H68N14O10
CAS Number
189691-06-3
Purity
≥99%
Reconstitution
BAC water
Overview
Receptor-targeted peptides bind specific G-protein-coupled or nuclear receptors to probe pharmacology in neuropsychiatric, dermatological, or sleep-related pathways.
PT-141 is studied for its activity at MC3R / MC4R, with a reported half-life of ~2 hr. The compound is supplied as a lyophilized powder and reconstituted with bac water prior to use in laboratory research.
Mechanism of Action
GPCR-mediated cAMP / Ca²⁺ signaling specific to the target receptor family.
In published in-vitro work, PT-141 engages MC3R alongside related receptor subtypes to initiate downstream signaling. The reported half-life of ~2 hr informs typical dosing intervals in experimental protocols.
Research Applications
- Receptor binding affinity assays
- Behavioral pharmacology in animal models
- Intranasal delivery and CNS penetration studies
- Comparative selectivity against close analogs
Handling & Reconstitution
Reference guidance for laboratory handling.
- Storage: -20°C lyophilized. Avoid repeated freeze-thaw cycles.
- Reconstitution: BAC water. Add diluent slowly down the side of the vial; gentle swirl, do not shake.
- Stability: Once reconstituted, store at 2–8°C and use within 14–28 days depending on peptide stability.
- Working solution: Calculate target concentration before reconstitution. Our calculator can help.
Quality & Verification
- Every batch of PT-141 we ship is third-party tested by an ISO-accredited lab. Each order arrives with a batch-matched Certificate of Analysis showing HPLC purity (≥99%), mass spectrometry confirmation of 1025.2 Da, and endotoxin / bioburden screening where applicable.
Related Entries
Senolytic research
Antioxidant pathway research
NAD metabolism research
Mitochondrial protection research
Shop PT-141
≥99% purity · third-party tested · ships from the USA